Q: http://www.msicomputer.com/product/p_spec.asp?model=P35_Neo-F
A: Those two will work perfectly with one another. Each are PCI-Express so you should be good to go with the slot. I would make sure that there is plenty of power to power the board with that graphics card. It takes a good bit to keep running properly. Sample Graphics Card that I pulled info from: http://www.newegg.com/Product/Product.aspx?Item=N82E16814127359 Take care, Chad