Gaming disadvantages to 64-bit vs. 32-bit?

Q: I wanted to know if there are any gaming disadvantages if you get a 64-bit Vista with 4GB RAM Vs. a 32-bit with 32-bit RAM. Can games not made for 64-bit still play? Do they run a lot slower? What exactly is a 32-bit and 64-bit and how are they different?

A: I game on 64 bit Vista and it works fine. Many games (such as crysis) have a 64bit mode.

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